TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000320623
  • Gene Name:NQO1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:Nrf2 signaling pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB01065
  • Drug Name:Melatonin
  • Drug Method:up-regulated the gene expression

Disease basic infommation

  • Disease:immunotoxicity induced by aluminum chloride (ALCL3) in spleen
  • Tissue:patients tissues

Other information

  • Title:Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway
  • Journal:Ecotoxicology And Environmental Safety
  • Published:2019
  • PubMed ID:30771656
  • Abstract:The present study aimed to investigate whether melatonin (MT) treatment can attenuate immunotoxicity induced by aluminum chloride (AlCl3) in rat spleen. Forty-eight healthy male Wistar rats were randomly allocated and treated with AlCl3and/or MT. Rats were orally administered with AlCl3for 90 days, from 61st days, rats were injected intraperitoneally with MT for 30 days. Firstly, we found that MT relieved the AlCl3-induced immunosuppression by improving spleen structural damage, CD3+and CD4+T lymphocyte subsets, IL-2 and TNF-α mRNA expressions and decreasing CD8+T lymphocyte subsets. Secondly, MT attenuated the AlCl3-induced oxidative stress in rat spleen by decreasing the levels of ROS and MDA, while increasing the activities of SOD and CAT. Thirdly, MT relieved the AlCl3-induced apoptosis in rat spleen by increasing the MMP and Bcl-2 mRNA and protein expressions, while decreasing apoptosis rates, activity of Caspase-3 and pro-apoptotic gene expression. Finally, MT increased Nrf2 nuclear translocation, and Nrf2 target genes (HO-1, NQO1, SOD1 and CAT) mRNA expressions in the spleen of AlCl3-exposed rat. These results suggest that MT may alleviate AlCl3-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway, which could lay the foundation for the treatment of AlCl3immunotoxicity.
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