TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000244741
  • Gene Name:CDKN1A (P21)
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:Northern blot
  • mRNA Pathway:P53 signaling pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB01055 (APRD00647)
  • Drug Name:Mimosine
  • Drug Method:up-regulated the gene expression

Disease basic infommation

  • Disease:breast cancer
  • Tissue:cell line (21PT)

Other information

  • Title:p21WAF1/CIP1/SDI1 is elevated through a p53-independent pathway by mimosine
  • Journal:Cell Growth Differ
  • Published:1996
  • PubMed ID:8809407
  • Abstract:Tumor suppressor p53 is a nuclear protein that is induced by DNA damage and is involved in G1 and G2 phase control of the cell cycle. p21WAF1/CIP1/SDI1 (p21), a cyclin-dependent kinase inhibitor, is a downstream target and effector of p53 to induce G1 arrest. Mimosine is a potent reversible late G1 phase blocker of the cell cycle. In this study, we showed that mimosine can increase both p21 mRNA and protein levels, indirectly inhibit cyclin E-associated kinase activity without affecting the cyclin E protein level, block human breast cancer cells (21PT) in the late G1 phase of the cell cycle, and induce a p53-independent p21 pathway in these cells. These results support the possibility of restoring a G1 checkpoint by use of mimosine. They also suggest that the mechanism of the effect of mimosine is complex and may have more than one target in the cell.
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