TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000344327
  • Gene Name:TRPC6
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB00678
  • Drug Name:Losartan
  • Drug Method:down-regulated the gene expression

Disease basic infommation

  • Disease:glomerulopathy
  • Tissue:tissues

Other information

  • Title:Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes
  • Journal:Journal of The Renin-angiotensin-aldosterone System
  • Published:2015
  • PubMed ID:25795457
  • Abstract:Objective:In this study, we investigated the molecule mechanisms of podocyte injury and proteinuria and the protective effects of losartan. Methods:This study set up three groups: a control group; an Ang II group (Ang II 10(-6) mol/l, Sigma); and a losartan group (losartan 10(-6) mol/l, Sigma). We used RT-PCR assay to detect TRPC6 mRNA expression, and Western blot to detect TRPC6 protein expression. Results:TRPC6 overexpression was the basic change of podocyte injury and proteinuria occurrence. Losartan can treat podocyte injury and proteinuria induced by Ang II via downregulation of TRPC6 in podocytes. Conclusion:These findings maybe provide an ideal drug target for the diagnosis and treatment of acquired glomerular diseases.
@Copyright Harbin Medical University
　The 2nd Affiliated Hospital of Harbin Medical University
　 备案号：鲁ICP备2022025566号-3