TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000266970
  • Gene Name:CDK2
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:papillary thyroid cancer
  • Tissue:The human PTC cell lines TPC1, K1 and human HEK293 T cells

Other information

  • Title:MiR-506-3p suppresses papillary thyroid cancer cells tumorigenesis by targeting YAP1
  • Journal:Pathology, research and practice
  • Published:2020
  • PubMed ID:33059240
  • Abstract:Thyroid cancer (TC) is the most common endocrine cancer in the world and about 80-85 % patients with TC belong to papillary thyroid cancer (PTC). MicroRNAs(MiRNAs) are a class of non-coding RNAs that can negatively modulate gene expression post-transcriptionally and play a role in tumorigenesis and development. The purpose of this study was to explore the biological function of miR-506-3p in PTC. We found that miR-506-3p suppressed cell proliferation disrupted the cell cycle of PTC cells in vitro. Mechanistically, we found that YAP1 was a direct target gene of miR-506-3p. Western Blot and RT-qPCR results indicated that miR-506-3p could down-regulate the expression of YAP1 at both mRNA and protein levels. Furthermore, miR-506-3p could also suppress the expression of CDK2/Cyclin E1 compound which could be affected by YAP1 gene. Therefore miR-506-3p might have proliferation-suppressive function in PTC by inhibiting YAP1 expression and regulating YAP1-CDK2/Cy clin E1 cell cycle pathway.
@Copyright Harbin Medical University
　The 2nd Affiliated Hospital of Harbin Medical University
　 备案号：鲁ICP备2022025566号-3