TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000320356
  • Gene Name:EZH2
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:EZH2 signaling pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB12025
  • Drug Name:Triptolide
  • Drug Method:down-regulated the gene expression the gene expression

Disease basic infommation

  • Disease:prostate cancer
  • Tissue:cell lines (PC-3,LNCaP)

Other information

  • Title:Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate cancer cells
  • Journal:Asian Pac J Cancer Prev
  • Published:2013
  • PubMed ID:24289559
  • Abstract:The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it is unknown whether its therapeutic effect relates with EZH2 in PCa. Here we described EZH2 as a target for Triptolide in PCa cells. Our data showed that Triptolide suppressed PCa cell growth and reduced the expression of EZH2. Overexpression of EZH2 attenuated the Triptolide induced cell growth inhibition. Moreover, Triptolide treatment of PC-3 cells resulted in elevated mRNA levels of target genes (ADRB2, CDH1, CDKN2A and DAB2IP) negatively regulated by EZH2 as well as reduced mRNA levelsan of EZH2 positively regulated gene (cyclin D1). Our findings suggest the PCa cell growth inhibition mediated by Triptolide might be associated with downregulation of EZH2 expression and the subsequent modulation of target genes.
@Copyright Harbin Medical University
　The 2nd Affiliated Hospital of Harbin Medical University
　 备案号：鲁ICP备2022025566号-3