TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000349945
  • Gene Name:NFAT5
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:non-small cell lung cancer
  • Tissue:Human lung cancer cell lines A549 and H1299

Other information

  • Title:miR-194 suppresses high glucose-induced non-small cell lung cancer cell progression by targeting NFAT5
  • Journal:Thorac Cancer
  • Published:2019
  • PubMed ID:30900402
  • Abstract:Background:Diabetes mellitus (DM) is linked to an increased risk of lung cancer; however, the exact molecular basis is unclear. Methods:We used a microarray method and found a group of microRNAs differently expressed in lung cancer cells at high or low glucose treatment. Results:Among these, miR-194 changed significantly, which indicated further analysis. miR-194 was significantly downregulated in non-small cell lung cancer (NSCLC) cells cultured in high glucose (HG) medium and clinical NSCLC tissues with DM. The introduction of miR-194 significantly suppressed the proliferation, migration, and invasion of lung cancer cells induced by HG, suggesting that miR-194 may be a suppressor during HG-induced NSCLC progression. Further analysis indicated that NFAT5 was a direct target gene of miR-194, evidenced by the direct binding of miR-194 with the 3＇untranslated region of NFAT5. MiR-194 could decrease the expression of NFAT5 at both messenger RNA and protein levels, while overexpression of NFAT5 reversed the decreased proliferation, migration, and invasion ability mediated by miR-194 in lung cancer cells. Conclusion:Our findings provide new insight into the mechanism of NSCLC progression. Therapeutically, miR-194 may serve as a potential target for the treatment of lung cancer patients with DM.
@Copyright Harbin Medical University
　The 2nd Affiliated Hospital of Harbin Medical University
　 备案号：鲁ICP备2022025566号-3