TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000372330
  • Gene Name:MMP9
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:primary lung adenocarcinoma
  • Tissue:Human lung adenocarcinoma cell lines (A549, H1299, and H322) and an immortalized human bronchial epithelial cell line (16HBE)

Other information

  • Title:Interleukin-32 contributes to invasion and metastasis of primary lung adenocarcinoma via NF-kBinduced matrix metalloproteinases 2 and 9 expression.
  • Journal:Cytokine
  • Published:2014
  • PubMed ID:24140068
  • Abstract:Interleukin (IL)-32 is a novel proinflammatory cytokine, which has been shown to play an important role in tumor growth and metastasis. Here, we discovered that IL-32 was aberrantly over-expressed in lung adenocarcinoma tissues and cell lines. Positive expression of IL-32 significantly correlated with the clinical staging, and lymph node and distant metastases. High expression of IL-32 was an independent indicator of poor prognosis in lung adenocarcinoma patients. Moreover, IL-32-facilitated cell migration and invasion in vitro was mediated through transactivation of the nuclear transcription factor (NF)-κB signaling pathway and subsequent upregulation of matrix metalloproteinase (MMP)-2 and MMP9 expression. These studies demonstrate that IL-32 plays a role in the tumor-associated inflammatory microenvironment and that overexpression of IL-32 contributes to invasion and metastasis in primary lung adenocarcinoma, suggesting that it may have clinical utility as a prognostic biomarker and potential target for immunotherapy in lung adenocarcinoma.
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