TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000263341
  • Gene Name:IL1B
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:qPCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB18665
  • Drug Name:Psoralen
  • Drug Method:down-regulated the gene expression

Disease basic infommation

  • Disease:periodontitis
  • Tissue:patients tissues

Other information

  • Title:Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
  • Journal:Scientific Reports
  • Published:2021
  • PubMed ID:33888745
  • Abstract:Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.
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