TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000368002
  • Gene Name:USP21
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:Wnt pathway
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:pancreatic cancer
  • Tissue:The hTERT-HPNE E6/E7 and hTERT-HPNE E6/E7-KRASG12D cells

Other information

  • Title:USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation
  • Journal:GENES & DEVELOPMENT
  • Published:2019
  • PubMed ID:31488580
  • Abstract:The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification of USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). USP21 overexpression correlates with human PDAC progression, and enforced expression of USP21 accelerates murine PDAC tumor growth and drives PanIN to PDAC progression in immortalized human pancreatic ductal cells. Conversely, depletion of USP21 impairs PDAC tumor growth. Mechanistically, USP21 deubiquitinates and stabilizes the TCF/LEF transcription factor TCF7, which promotes cancer cell stemness. Our work identifies and validates USP21 as a PDAC oncogene, providing a potential druggable target for this intractable disease.
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