TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000263923
  • Gene Name:KDR
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:AKT
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:ovarian cancer
  • Tissue:Human OVCAR-3 ovarian cancer cells

Other information

  • Title:miRNA-195 suppresses cell proliferation of ovarian cancer cell by regulating VEGFR2 and AKT signaling pathways.
  • Journal:Mol Med Rep.
  • Published:2018
  • PubMed ID:29845300
  • Abstract:The present study aimed to investigate the functional effects of microRNA-195 on ovarian cancer cells and the underling mechanism involved. Reverse transcription-quantitative polymerase chain reaction was used to measure the expression of microRNA-195 in patients with ovarian cancer. Cell proliferation and apoptosis were measured with MTT assay and flow cytometry, respectively. Caspase-3/9 activity, vascular endothelial growth factor receptor (VEGFR)2 and phosphorylated protein kinase B (p-AKT) protein expression were analyzed using caspase-3/9 activity kits and western blot analysis. The expression of microRNA-195 was downregulated in ovarian cancer, compared with the normal control group. Furthermore, microRNA-195 suppresses cell proliferation and induced apoptosis of ovarian cancer cells. In addition, microRNA-195 suppressed VEGFR2 and p-AKT protein expression in ovarian cancer cells. The inhibition of VEGFR2 and p-AKT increased the functional effects of microRNA-195 on apoptosis of ovarian cancer cells. The results demonstrated that microRNA-195 suppresses cell proliferation of ovarian cancer cells through regulation of VEGFR2 and AKT signaling pathways.
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