TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000379561
  • Gene Name:FOXO1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:osteosarcoma
  • Tissue:Osteosarcoma cell lines

Other information

  • Title:Liver X receptor α inhibits osteosarcoma cell proliferation through up-regulation of FoxO1.
  • Journal:Cell Physiol Biochem
  • Published:2013
  • PubMed ID:23867395
  • Abstract:Background:Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. Methods:We analyzed liver X receptor α (LXRα) mRNA expression in 16 pairs of human osteosarcoma tissues and adjacent noncancerous tissues. Moreover, we investigated LXRα＇s potential role in regulating cell proliferation in Saos-2 and U2OS cells. Results:We found that activation of LXRα, a member of nuclear receptor, was able to inhibit cell proliferation in Saos-2 and U2OS cells. At the molecular level, our results further revealed that expression of tumor suppressor gene, FoxO1, was up-regulated by LXRα activation. LXRα activates FoxO1 transcription through a direct binding on its promoter region. Conclusion:LXRα acts as a tumor suppressor for osteosarcoma, which may offer a new way in molecular targeting cancer treatment.
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