TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000310823
  • Gene Name:ADAM17
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:oral squamous cell cancer (oscc)
  • Tissue:An OSCC cell line, SAS

Other information

  • Title:Involvement of NF-kB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma
  • Journal:Biochemical and biophysical research communications
  • Published:2008
  • PubMed ID:17999917
  • Abstract:The involvement of a disintegrin and metalloprotease domain (ADAM)-17 on the cancer invasion was investigated in oral squamous cell carcinoma (OSCC) cells. TNFalpha induced the conversion from the proform of ADAM-17 to its mature form time-dependently. TNFalpha also cleaved CD44 to its small fragments, as observed by a Western blot analysis. The transfection of ADAM-17 siRNA partially suppressed the expression of ADAM-17 as well as the cleavage of CD44. On the other hand, TNFalpha activated a transcription factor NF-kappaB in OSCC cells, while NBD peptide, an NF-kappaB inhibitor, inhibited the ADAM-17 maturation, thus suggesting that NF-kappaB is involved in ADAM-17 maturation. Moreover, an in vitro invasion assay revealed that both ADAM-17 siRNA and NBD peptides strongly suppressed the TNFalpha-induced invasion of OSCC cells through the matrix. In conclusion, ADAM-17 plays an important role in cancer invasion probably through CD44 cleavage.
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