TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000389614
  • Gene Name:GPX2
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB00633
  • Drug Name:Dexmedetomidine
  • Drug Method:down-regulated the gene expression

Disease basic infommation

  • Disease:myocardial ischemia-reperfusion injury
  • Tissue:tissue

Other information

  • Title:Effects of dexmedetomidine on myocardial ischemia-reperfusion injury through PI3K-Akt-mTOR signaling pathway
  • Journal:European Review For Medical And Pharmacological Sciences
  • Published:2019
  • PubMed ID:31378917
  • Abstract:Objective:To explore the role of dexmedetomidine (DEX) in myocardial ischemia-reperfusion (I/R) injury model and investigate its specific molecular mechanism. Conclusions:DEX can play a protective role in myocardial I/R rats, improve the cardiac function of I/R rats, eliminate oxygen free radicals, relieve oxidative stress injury, inhibit inflammatory responses and reduce the release of CK and other substances. The myocardial protection effects of DEX are mainly achieved through the phosphatidylin-ositol-3-kinase (PI3K)-Akt-mTOR pathway.
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