TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000327443
  • Gene Name:SP1
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:SP1 signlaing pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB04216 (EXPT02732)
  • Drug Name:Quercetin
  • Drug Method:down-regulated the gene expression the gene expression

Disease basic infommation

  • Disease:malignant mesothelioma
  • Tissue:cell lines (MSTO-211H)

Other information

  • Title:Role of transcription factor Sp1 in the quercetin-mediated inhibitory effect on human malignant pleural mesothelioma
  • Journal:Int J Mol Med
  • Published:2012
  • PubMed ID:22842769
  • Abstract:Quercetin (Qu) is found in plants, including red onions and in the skins of red apples, and induces the apoptosis of certain malignant cells. However, no report has been issued on the apoptotic effect of Qu on human malignant pleural mesothelioma. In the present study, it was found that MSTO-211H mesothelioma cell viability was reduced and apoptotic cell death was increased by Qu (20-80 μM), which was found to have an IC?? of 58 μM. In addition, Qu increased the sub-G? cell population, and was found to interact with specificity protein 1 (Sp1) and significantly suppressed its expression at the protein and mRNA levels. Furthermore, Qu modulated the levels of Sp1 regulatory genes, such as cyclin D1, myeloid cell leukemia (Mcl)-1 and survivin in MSTO-211H cells. Apoptotic signaling cascades were activated by the cleavage of Bid, caspase-3 and PARP, and by the downregulation of Bcl-xL and the upregulation of Bax in MSTO-211H cells. Our results strongly suggest that Sp1 be considered as a novel molecular target of Qu in human malignant pleural mesothelioma.
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