TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000378538
  • Gene Name:SPI1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:leukemia
  • Tissue:U937, U937NC, U937shPU.1, U937Tempty and U937TFLAG-PU.1

Other information

  • Title:PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells.
  • Journal:FEBS Lett
  • Published:2011
  • PubMed ID:21176776
  • Abstract:RIG-G is a retinoic acid- or interferon-induced gene with potential anti-proliferation function. However, the mechanism underlying ATRA-induced RIG-G induction is not completely understood. Here, we demonstrate that ATRA up-regulates the expression of PU.1, which in turn directly binds to the promoter and increases the expression of RIG-G gene. Luciferase reporter assay and electrophoretic mobility shift assay reveal that PU.1 preferentially binds to one of the two putative binding sites on the RIG-G promoter. Moreover, silencing of PU.1 by shRNA markedly inhibited ATRA- but not IFNα-induced expression of RIG-G. These data provide new insight into the mechanism of ATRA-induced RIG-G expression.
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