TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000341911
  • Gene Name:MYB
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:laryngeal squamous cell cancer
  • Tissue:Patient samples

Other information

  • Title:YB-1 promotes laryngeal squamous cell carcinoma progression by inducing miR-155 expression via c-Myb.
  • Journal:Future Oncol
  • Published:2018
  • PubMed ID:29517281
  • Abstract:Aim:In this study, we investigated the role of Y-box binding protein-1 (YB-1), c-Myb and miR-155 in human laryngeal squamous cell carcinoma (LSCC) progression. Materials & methods:Quantitative real-time PCR, western blot, MTT and Transwell were conducted to determine the expression and function of YB-1/miR-155 pathway. Univariate and multivariate analyses were used to determine the prognostic factors. Results:Expression of YB-1, c-Myb and miR-155 was higher in LSCC tissues. YB-1 promoted proliferation, invasiveness and migration of Hep-2 cells in vitro. Patients with higher YB-1 correlated with advanced T stage, poor differentiation and cervical metastasis. LSCC patients with high YB-1 expression showed poor overall survival. Conclusion:YB-1 promotes LSCC progression by increasing miR-155 levels via c-Myb and acts as a prognostic factor.
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