TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000621592
  • Gene Name:MYC
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:head and neck cancer
  • Tissue:SAS, OECM-1, Fadu and HSC-3 HNSCC cells, HaCaT immortalized skin keratinocyte cell line and normal human oral keratinocyte (NHOK)

Other information

  • Title:miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
  • Journal:Cancer Lett
  • Published:2013
  • PubMed ID:23726841
  • Abstract:miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFβRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies.
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