TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000267163
  • Gene Name:RB1
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:gastric cancer
  • Tissue:The biological characteristics and cultivation methods of gastric cell lines, including AGS BGC-823, GES1, HGC-27, MGC-803, NCI-N87 and SGC-7901 cell lines

Other information

  • Title:MiR-215 modulates gastric cancer cell proliferation by targeting RB1
  • Journal:Cancer letters
  • Published:2014
  • PubMed ID:23981575
  • Abstract:Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3＇-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.
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