TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000451137
  • Gene Name:CCN1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:Sheng-ji Hua-yu ointment
  • Drug Method:up-regulated the gene expression

Disease basic infommation

  • Disease:diabetic ulcers
  • Tissue:patients tissues

Other information

  • Title:Sheng-ji Hua-yu ointment ameliorates cutaneous wound healing in diabetes via up-regulating CCN1
  • Journal:Journal of Ethnopharmacology
  • Published:2022
  • PubMed ID:36435409
  • Abstract:Aim of the study:In order to verify the underlying mechanism of SJHY ointment in accelerating the closure of DUs. Materials and methods:Modular pharmacology and molecular docking were utilized to predict the therapeutic targets of SJHY ointment against DUs. Male db/db diabetic mice and HaCaT cell models induced by methylglyoxal were used to validate the findings. Results:CCN1 was proven to be the core target of SJHY ointment involved in DUs treatment. CCN1 up-regulated by SJHY treatment (0.5 g/cm2/day) at the mRNA and protein levels was detected on Day9 after wounding. With CCN1 knockdown, accelerated cell proliferation, migration, and anti-inflammatory effect of SJHY treatment (10 mg/L) were reversed. Conclusions:SJHY ointment ameliorates cutaneous wound healing by up-regulating CCN1.
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