TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000333511
  • Gene Name:BSG
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:colorectal cancer
  • Tissue:Cell lines HCT116, HT29, HCT8 (human colon cancer cell lines) and FHC (normal human intestinal epithelial cell line)

Other information

  • Title:The inhibitory role of miR-485-5p in colorectal cancer proliferation and invasion via targeting of CD147
  • Journal:Oncology reports
  • Published:2018
  • PubMed ID:29532886
  • Abstract:Recently, miR-485-5p was identified as a tumor-suppressing microRNA in some human cancers. However, the expression and biological role of miR-485-5p in colorectal cancer (CRC) remain unclear. Herein, we found that the expression of miR-485-5p in CRC tissues and cell lines was much lower than that in the control, respectively. Moreover, the overexpression of miR-485-5p could inhibit the proliferation and invasion of CRC cell lines in vitro and in vivo. Furthermore, we determined that miR-485-5p could decrease the expression of CD147 by directly targeting CD147 3＇UTR. In addition, the expression of CD147 was inversely correlated with the expression of miR-485-5p in CRC tissues. Collectively, our results revealed that miR-485-5p played a pivotal tumor-suppressing role in CRC through downregulation of cancer-associated gene CD147, and may provide a better understanding of the pathogenesis in CRC and a new bio-target for CRC therapy.
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