TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000282441
  • Gene Name:YAP1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:Hippo
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:colorectal cancer
  • Tissue:Human colon adenocarcinoma cell lines: HCT116 (ATCC Cat# CCL‐ 247, RRID:CVCL_0291), SW480 (ATCC Cat# CCL‐228, RRID: CVCL_0546), DLD‐1 (ATCC Cat# CCL‐221, RRID:CVCL_0248), HT29 (ATCC Cat# HTB‐38, RRID:CVCL_0320), and HEK‐293T (ATCC Cat# CRL‐3216, RRID:CVCL

Other information

  • Title:Loss of HACE1 promotes colorectal cancer cell migration via upregulation of YAP1.
  • Journal:Journal of cellular physiology
  • Published:2019
  • PubMed ID:30362561
  • Abstract:Colorectal cancer (CRC) is the third-leading cause of cancer mortality worldwide. HACE1 function as a tumor-suppressor gene and is downregulated in several kinds of cancers. However, the distribution and clinical significance of HACE1 in CRC is still not clarified. In this study, we found that the HACE1 expression is greatly downregulated in CRC tissues and cell lines. Moreover, the HACE1 expression was significantly associated with inhibition of CRC cell proliferation, metastasis, and invasion. HACE1 inhibited epithelial-mesenchymal transition in CRC cells. Furthermore, we found that HACE1 altered the protein expression of the Hippo pathway by downregulation of YAP1. HACE1 suppresses the invasive ability of CRC cells by negatively regulating the YAP1 pathway. Our data indicates that HACE1 directly targets YAP1 and induces downregulation of YAP1, thereby increasing the activity of the Hippo pathway. In summary, these findings demonstrated that HACE1-YAP1 axis had an important part in the CRC development and progression.
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