TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000353267
  • Gene Name:CREB1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:colon cancer
  • Tissue:Patient samples

Other information

  • Title:Overexpression of microRNA-101 causes anti-tumor effects by targeting CREB1 in colon cancer.
  • Journal:Mol Med Rep
  • Published:2019
  • PubMed ID:30816471
  • Abstract:Accumulating evidence has demonstrated that aberrantly expressed microRNAs (miRNAs) are involved in the initiation and progression of numerous types of human cancer. Although a number of miRNAs have been demonstrated to be associated with the diagnosis, progression and prognosis of colon cancer, the function of miRNA-101 (miR-101) in colon cancer remains unclear, and the molecular mechanisms underlying the effects of miR-101 in colon cancer require further investigation. The present study investigated the role of miR-101 in colon cancer, and the results suggested that miR-101 expression levels were significantly decreased in colorectal carcinoma tissues and in three types of colorectal cancer cell lines. Furthermore, overexpression of miR-101 inhibited cell proliferation and migration in HT29 cells. The transcription factor cAMP responsive element binding protein 1 (CREB1) was identified to be a direct target of miR-101 using a luciferase reporter assay, reverse transcription-quantitative polymerase chain reaction analysis and western blot assay. miR-101 overexpression in tumor xenografts in vivo decreased the expression levels of proliferating cell nuclear antigen and CREB1, and suppressed tumor growth. The present results suggested that miR-101 may serve a role in colon cancer by directly targeting CREB1. Collectively, the present study may contribute to the development of improved diagnosis and prognostics for colon cancer.
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