TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000368738
  • Gene Name:S100A9
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:Semi-Quantitative RT-PCR
  • mRNA Pathway:Wnt/β-catenin
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:cervical cancer
  • Tissue:The human embryonic kidney cell line 293 and the human cervical cancer cell lines SiHa, CaSki, and HeLa

Other information

  • Title:S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial-mesenchymal transition and activating the Wnt/β-catenin pathway.
  • Journal:Int J Oncol
  • Published:2019
  • PubMed ID:31059008
  • Abstract:S100 calcium鈥慴inding protein A9 (S100A9), a member of the S100 protein family, is often upregulated in various cancers, including cervical cancer. Elevated S100A9 expression is thought to serve an important role in tumorigenesis; however, the exact role of S100A9 in the modulation of cervical cancer and the underlying molecular mechanism remain unknown. In the present study, we aimed to investigate the effects of S100A9 on the proliferation and migration of cervical cancer cells, as well as the molecular mechanisms underlying these effects. Our results demonstrated that endogenous expression of S100A9 in SiHa and CaSki cell lines was significantly higher than in the HeLa cell line. As expected, overexpression of S100A9 enhanced the proliferation and migration of cervical cancer cells. In addition, S100A9 overexpression induced epithelial鈥憁esenchymal transition (EMT) as determined by reduced expression levels of the epithelial marker E鈥慶adherin, whereas the expression levels of the mesenchymal marker vimentin were upregulated. Furthermore, it was reported that the effects of S100A9 in the modulation of cervical cancer cells were mediated through the Wnt/β鈥慶atenin signaling pathway as β鈥慶atenin knockdown significantly suppressed the ability of S100A9 to enhance the proliferation and migration of cervical cancer cells. Collectively, these findings suggest that S100A9 promoted the proliferation and migration of cervical cancer cell lines. Furthermore, the underlying molecular mechanisms may be partially attributed to the induction of EMT and activation of the Wnt/β鈥慶atenin signaling pathway.
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