TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000369501
  • Gene Name:CB1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:AKT signaling pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB00470 (APRD00571)
  • Drug Name:Dronabinol
  • Drug Method:up regulated the gene expression

Disease basic infommation

  • Disease:rhabdomyosarcoma
  • Tissue:cell lines (Rh4 and Rh28)

Other information

  • Title:Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
  • Journal:Mol Cancer Ther
  • Published:2009
  • PubMed ID:19509271
  • Abstract:Gene expression profiling has revealed that the gene coding for cannabinoid receptor 1 (CB1) is highly up-regulated in rhabdomyosarcoma biopsies bearing the typical chromosomal translocations PAX3/FKHR or PAX7/FKHR. Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated whether CB1 is a potential drug target in rhabdomyosarcoma. Our study shows that treatment with the cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis. This effect relies on inhibition of AKT signaling and induction of the stress-associated transcription factor p8 because small interfering RNA-mediated down-regulation of p8 rescued cell viability upon cannabinoid treatment. Finally, treatment of xenografts with HU210 led to a significant suppression of tumor growth in vivo. These results support the notion that cannabinoid receptor agonists could represent a novel targeted approach for treatment of translocation-positive rhabdomyosarcoma.
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