TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000375123
  • Gene Name:FOXE1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB01262
  • Drug Name:5-Aza-2-deoxycytidine (5-Aza-CdR)
  • Drug Method:demethylating the promoter to induce the mRNA expression

Disease basic infommation

  • Disease:squamous cell carcinoma
  • Tissue:cell lines and patients tissues

Other information

  • Title:FOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma
  • Journal:Br J Dermatol
  • Published:2010
  • PubMed ID:19845668
  • Abstract:Background:Several cancer-related genes are silenced by promoter hypermethylation in skin cancers. However, to date the somatic epigenetic events that occur in cutaneous squamous cell carcinoma (SCC) tumorigenesis have not been well defined. Objectives:To examine epigenetic abnormalities of FOXE1, a gene located on chromosome 9q22, a region frequently lost in SCC. Methods:We investigated the methylation status of FOXE1 in 60 cases of cutaneous SCC by methylation-specific polymerase chain reaction, and comparatively examined mRNA and protein expression by real-time polymerase chain reaction and Western blot, respectively. Results:We found a higher frequency of FOXE1 promoter hypermethylation in SCCs (55%), as compared with the adjacent uninvolved skin (12%) and blood control samples (9.5%). FOXE1 methylation was frequently seen in association with a complete absence of or downregulated gene expression. Treatment with the demethylating agent 5-Aza-2＇-deoxycytidine resulted in profound reactivation of FOXE1 expression. Conclusions:These results indicate that FOXE1 is a crucial player in development of cutaneous SCC.
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