TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000620103
  • Gene Name:MUC1
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:qRT-PCR
  • mRNA Pathway:lincRNA-ROR/miR-145
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:triplenegative breast cancer
  • Tissue:The BC cell lines MCF-10A, MCF-7, BT474, MDA-MB-453 and MDA-MB-231

Other information

  • Title:LincRNA-RoR/miR-145 promote invasion and metastasis in triple-negative breast cancer via targeting MUC1
  • Journal:Biochemical and biophysical research communications
  • Published:2018
  • PubMed ID:29673594
  • Abstract:Triple-negative breast cancer (TNBC) was associated with high rates of cancer recurrence and metastasis and currently no available molecularly target. Accumulating evidences have established the importance of lincRNA-ROR as a marker of cancers. In order to better understand the mechanism of lincRNA-ROR in TNBC, we provided a novel molecular target into the regulatory invasion and metastasis in present research. We found that lincRNA-ROR was upregulated in TNBC cell lines and tissue samples. The aberrant expression of lincRNA-ROR was shown to increase invasion and metastasis in MDA-MB-231 and loss of function by siRNA reverse these process. Furthermore, lincRNA-ROR functions as a competing endogenous RNAs (ceRNA) which sponges miR-145 and therefore upregulate the expression of Mucin1 (MUC1). The expression of MUC1 impacted E-cadherin membrane localization. Together, MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR-145 for invasion and metastasis in TNBC cell lines.
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