TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000379440
  • Gene Name:PRNP
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:Semi-Quantitative RT-PCR
  • mRNA Pathway:NA
  • Evidence:predicted
  • (mRNA-drug)

Drug basic information

  • Drug ID:NA
  • Drug Name:NA
  • Drug Method:NA

Disease basic infommation

  • Disease:breast cancer
  • Tissue:MCF-7 and MDA-MB231

Other information

  • Title:Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity.
  • Journal:Biochemical and biophysical research communications
  • Published:2016
  • PubMed ID:26778001
  • Abstract:Function of cellular prion protein (PrP(c)) in cancer progression has not been elucidated yet. Ectopic expression of PrP(c) increases the invasion and migration of breast cancer cell line, MCF-7 cells. Overexpressed PrP(c) increases matrix metalloprotease-9 (MMP-9) expression by enhancing association of NF-κB in promoter of MMP-9 gene and ERK signaling in MCF-7 cells. Whereas, silencing of PrP(c) by siRNA suppresses ERK activation and MMP-9 expression resulting the down-regulation of MD-MB231 cell migration and invasion. Overall, these results suggest that PrP(c) contribute the breast cancer invasion and migration via MMP-9.
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