TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000368507
  • Gene Name:ROS1
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB02709
  • Drug Name:Resveratrol
  • Drug Method:down-regulated the gene expression

Disease basic infommation

  • Disease:alzheimer＇s disease
  • Tissue:tissues

Other information

  • Title:Resveratrol inhibits oligomeric Aβ-induced microglial activation via NADPH oxidase
  • Journal:Molecular Medicine Reports
  • Published:2015
  • PubMed ID:26252250
  • Abstract:Microglia-mediated neuroinflammation is key in the pathogenesis of Alzheimer＇s disease (AD). Several studies have suggested that NADPH oxidase contributes to microglia-mediated neuroinflammation. Resveratrol, which is a natural polyphenolic compound, exerts neuroprotective effects in AD due to its anti-inflammatory properties. The present study aimed to investigate the effects of resveratrol on the activation of oligomeric amyloid β (oAβ)-induced BV-2 microglia, and to determine the role of NADPH oxidase in these effects. Microglial proliferation was measured by high-content screening cell counting and using a bromodeoxyuridine incorporation assay. In addition, the levels of reactive oxygen species (ROS), nitric oxide (NO), tumor necrosis factor (TNF)-α and interleukin (IL)-1β were assessed. The results of the present study demonstrated that resveratrol inhibited the proliferation of oAβ-induced microglia and the production of pro-inflammatory factors, including ROS, NO, TNF-α and IL-1β. Subsequent mechanistic investigations demonstrated that resveratrol inhibited the oAβ-induced mRNA and protein expression levels of p47phox and gp91phox. These results suggested that NADPH oxidase may be a potential target for AD treatment, and resveratrol may be a valuable natural product possessing therapeutic potential against AD.
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