TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000380743
  • Gene Name:SMN2
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB04216
  • Drug Name:Quercetin
  • Drug Method:up-regulated the gene expression

Disease basic infommation

  • Disease:spinal muscular atrophy
  • Tissue:tissues

Other information

  • Title:Effects of flavonoid quercetin on survival of motor neuron gene expression
  • Journal:Cell Biology International
  • Published:2015
  • PubMed ID:25319353
  • Abstract:Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that results in muscle weakness and atrophy. To attenuate disease severity, drug development studies have been applied mainly to target the Survival of Motor Neuron 2 (SMN2) gene, which is an important modifier of SMA. Although several compounds have been tested, there is still no cure for SMA. In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients. Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level.
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