TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000367866
  • Gene Name:OCT
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB04690
  • Drug Name:Camptothecin
  • Drug Method:up-regulated the gene expression

Disease basic infommation

  • Disease:cancer
  • Tissue:cell lines

Other information

  • Title:Increased level of Oct-1 protein in tumor cells modulates cellular response to anticancer drugs
  • Journal:Dokl Biochem Biophys
  • Published:2016
  • PubMed ID:27599509
  • Abstract:The effect of overexpression of Oct-1 protein isoforms on the cell response to two anticancer drugs camptothecin and dexamethasone was studied. The effect of Oct-1 isoforms on regulated gene transcription was estimated by the difference in the level of mRNA in Burkitt＇s lymphoma cells (Namalwa line) untransfected and stably transfected with Oct-1 isoforms. The response to anticancer drugs of the Oct-1 target genes involved in the development of apoptosis depended, firstly, on the type of drug, secondly, on the concentration of Oct-1 in cells. and, thirdly, on the Oct-1 isoform with which these cells were transfected.
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