TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000366930
  • Gene Name:TGFB2
  • mRNA database:Ensembl
  • mRNA expression :down-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:NA
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB04951
  • Drug Name:Pirfenidone
  • Drug Method:down-regulated the gene expression the gene expression

Disease basic infommation

  • Disease:glioma
  • Tissue:cell lines (LN-18, LN-229, LN-308,T98G)

Other information

  • Title:Pirfenidone inhibits TGF-beta expression in malignant glioma cells
  • Journal:Biochem Biophys Res Commun
  • Published:2007
  • PubMed ID:17234158
  • Abstract:Due to its immunosuppressive properties, the cytokine transforming growth factor (TGF)-beta has become a promising target in the experimental treatment of human malignant gliomas. Here, we report that the antifibrotic drug 5-methyl-1-phenyl-2-(1H)-pyridone (pirfenidone, PFD) elicits growth-inhibitory effects and reduces TGF-beta2 protein levels in human glioma cell lines. This reduction in TGF-beta2 is biologically relevant since PFD treatment reduces the growth inhibition of TGF-beta-sensitive CCL-64 cells mediated by conditioned media of glioma cells. The downregulation of TGF-beta is mediated at multiple levels. PFD leads to a reduction of TGF-beta2 mRNA levels and of the mature TGF-beta2 protein due to decreased expression and direct inhibition of the TGF-beta pro-protein convertase furin. In addition, PFD reduces the protein levels of the matrix metalloproteinase (MMP)-11, a TGF-beta target gene and furin substrate involved in carcinogenesis. These data define PFD or PFD-related agents as promising agents for human cancers associated with enhanced TGF-beta activity.
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