TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000261769
  • Gene Name:CDH1 (E-cadherin)
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:EMT signalin pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB00136 (NUTR00003, APRD00246, DB05314)
  • Drug Name:Calcitriol (1-alpha-25-Dihydroxyvitamin D3)
  • Drug Method:up regulated the gene expression

Disease basic infommation

  • Disease:breast cancer
  • Tissue:cell lines (MDA-MB-231)

Other information

  • Title:1Alpha,25-dihydroxyvitamin D3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation
  • Journal:Anticancer Res
  • Published:2012
  • PubMed ID:22213313
  • Abstract:Background:The triple-negative subgroup of breast cancer includes a cluster of tumors exhibiting low E-cadherin expression (metaplastic carcinomas). In several cancer models, 1 alpha,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) induces differentiation by increasing E-cadherin expression. The Vitamin D receptor (VDR) was evaluated as a possible therapeutic target for metaplastic carcinomas and 1α,25(OH)(2)D(3) effects as a differentiating agent in triple-negative breast cancer cells were assessed. Materials and methods:Metaplastic carcinomas were assessed for VDR expression by immunohistochemistry; differences in E-cadherin expression in triple-negative breast cancer cells were evaluated by real-time PCR, western blotting and Cadherin 1 (CDH1) methylation status. Results:Most of the metaplastic carcinomas were positive for VDR expression. Furthermore, 1α,25(OH)(2)D(3) promoted differentiation of MDA-MB-231 cells by inducing de novo E-cadherin expression, an effect that was time- and dose-dependent. Also, E-cadherin expression was due to promoter demethylation. Conclusion:Metaplastic carcinomas may respond to 1α,25(OH)(2)D(3), since they express VDR and 1α,25(OH)(2)D(3) induces de novo E-cadherin expression in breast cancer cells by promoter demethylation.
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