TargetRx Atlas

MRNA basic information

  • mRNA ID:ENST00000651735
  • Gene Name:PPARG (PPARgamma)
  • mRNA database:Ensembl
  • mRNA expression :up-regulated
  • mRNA Method:RT-PCR
  • mRNA Pathway:PPAR gamma signaling pathway
  • Evidence:validated
  • (mRNA-drug)

Drug basic information

  • Drug ID:DB11133
  • Drug Name:omega-3 fatty acids
  • Drug Method:up-regulated the gene expression

Disease basic infommation

  • Disease:gastric cancer
  • Tissue:patients tissues

Other information

  • Title:The effect of omega-fatty acids on mRNA expression level of PPARgamma in patients with gastric adenocarcinoma
  • Journal:Exp Oncol
  • Published:2016
  • PubMed ID:27685528
  • Abstract:Background:The antineoplastic role of peroxisome proliferator-activated receptor gamma (PPARγ) ligandshas previously been demonstrated in several gastric cancer cell lines. Activation of PPARγ by polyunsaturated fatty acids (PUFAs) inhibits growth and proliferationof tumor cells. In this double-blind clinical study, we evaluate the effect of PUFAs on PPARγ mRNA expression in patients with gastric adenocarcinoma. Materials and methods:A total of 34 chemotherapy-naive patients diagnosed with gastric adenocarcinoma were enrolled in the present study. According to treatment strategies, all subjects were divided into two groups, the first group (17 individuals) received cisplatin without supplements and the second group (17 individuals) received cisplatin plus orally administered PUFAs supplements for 3 weeks. The gastric biopsy samples were obtained from all participants before and after treatment, and PPARγ mRNA expression levels were evaluated by quantitative real-time polymerase chain reaction using validated reference genes. Results:Our findings revealed that PPARγ mRNA expression is significantly upregulated in group II afterreceiving cisplatin plus orally administered PUFAs supplements for three weeks (p < 0.0001), whereas PPARγ mRNA expression did not show significant alteration in group I after receiving cisplatin alone. Conclusion:The results of the study evidence that PPARγ may act as a potential target for the therapy of human gastric adenocarcinoma.
@Copyright Harbin Medical University
　The 2nd Affiliated Hospital of Harbin Medical University
　 备案号：鲁ICP备2022025566号-3